Radiolabeled Glass Beads in Treating Patients With Liver Cancer That Cannot be Removed by Surgery

    Not Recruiting
  • End date
    Aug 31, 2027
  • participants needed
  • sponsor
    Ohio State University Comprehensive Cancer Center
Updated on 20 October 2022
liver cancer
tumor cells
liver mass
alpha fetoprotein
hepatocellular carcinoma
unresectable hepatocellular carcinoma
yttrium y 90 glass microspheres


This clinical trial studies radiolabeled glass beads (yttrium Y 90 glass microspheres) in treating patients with unresectable hepatocellular carcinoma. Internal radiation therapy uses radioactive material placed directly into or near a tumor to kill tumor cells. Using radiolabeled glass beads to kill tumor cells may be an effective treatment for liver cancer.



I. Provide oversight to treatment with TheraSphere to eligible patients with hepatocellular carcinoma (HCC) of the liver who are not surgical resection candidates.

II. Evaluate patient experience, toxicities and overall survival associated with TheraSphere treatment.


Patients receive yttrium Y 90 glass microspheres intra-arterially (IA) on day 0, and may receive a second dose within 30-90 days of initial treatment. Patients may receive additional treatment 4-12 weeks after initial treatment at the discretion of the study physician.

After completion of study treatment, patients are followed up at 3-6 weeks and annually for 2 years.

Condition Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
Treatment laboratory biomarker analysis, yttrium Y 90 glass microspheres
Clinical Study IdentifierNCT02072356
SponsorOhio State University Comprehensive Cancer Center
Last Modified on20 October 2022

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