Last updated on April 2018

Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial


Brief description of study

Heart failure (HF) is a major cardiovascular disease with increasing prevalence. Thiamine deficiency is common in HF patients. Previous small studies have shown that thiamine supplementation can improve left ventricular systolic function in HF, but larger clinical studies are lacking. Given the ease of supplementation and the potential benefits in HF, we aim to conduct a pilot randomized controlled trial (RCT) using high dose thiamine supplementation in HF patients. The main goal of this pilot study is to determine the feasibility of recruitment for an RCT of thiamine supplementation.

Clinical Study Identifier: NCT03228030

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Catherine Demers, MD, MSc, FRCPC

McMaster University
Hamilton, ON Canada
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Recruitment Status: Open


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