Fentanyl and Crushed Ticagrelor in Percutaneous Coronary Intervention (FACTPCI)

  • STATUS
    Recruiting
  • End date
    Dec 23, 2023
  • participants needed
    80
  • sponsor
    The Guthrie Clinic
Updated on 2 March 2022
ticagrelor

Summary

During a percutaneous coronary intervention (PCI), Fentanyl is commonly used for sedation. Ticagrelor is also routinely used as anti-platelet agent during PCI. However, a recent study has demonstrated the decrease in effectiveness of Ticagrelor when administered along with Fentanyl. Hence this study was designed to further assess the interaction between crushed vs non crushed Ticagrelor and Fentanyl given during PCI procedures.

Details
Condition Percutaneous Coronary Intervention
Treatment Fentanyl, Ticagrelor 90Mg Tablet
Clinical Study IdentifierNCT03476369
SponsorThe Guthrie Clinic
Last Modified on2 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Undergoing clinically indicated elective or non-elective PCI
Able to swallow oral medications

Exclusion Criteria

Contraindications to ticagrelor or fentanyl (or other opiates)
Pregnancy
Any use of P2Y12 inhibitors within 14 days
Known coagulation disorders
Pre-procedural treatment with an anticoagulant (oral anticoagulant or low molecular weight heparin)
Platelet count < 100,000/mm3
Impaired renal function (Estimated glomerular filtration < 45 ml/min/1.73 m2)
Impaired hepatic function (Based on medical history)
Prior or planned transcatheter aortic valve replacement
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