Last updated on June 2019

Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus


Brief description of study

This is an open-label multicenter, long-term extension safety study to evaluate the safety of IV CR845 administered after each dialysis session over a Treatment Period of up to 52 weeks.

Detailed Study Description

This is an open-label multicenter, long-term extension safety study to evaluate the safety of IV CR845 administered after each dialysis session over a Treatment Period of up to 52 weeks. This study will consist of a Screening Visit, a 52 week Treatment Period, and a Follow-up Visit. Informed consent will be obtained prior to performing any study-specific procedures. All patients will have a Screening Visit, which can be performed anytime within 14 days prior to the first dose of study drug, to confirm eligibility.

Clinical laboratory tests, electrocardiograms (ECGs), vital signs, adverse events, and concomitant medications will be monitored throughout the study. Blood samples for inflammatory biomarkers will be collected from all patients prior to dialysis on Day 1 and periodically until the End of Treatment or Early Termination Visit. Blood samples will also be collected periodically for clinical laboratory tests.

Clinical Study Identifier: NCT03281538

Find a site near you

Start Over

Cara Therapeutics Study Site

Long Beach, CA United States
  Connect »

Cara Therapeutics Study Site

El Centro, CA United States
  Connect »

Cara Therapeutics Study Site

Northridge, CA United States
  Connect »

Cara Therapeutics Study Site

Hollywood, FL United States
  Connect »

Cara Therapeutics Study Site

Winter Park, FL United States
  Connect »

Cara Therapeutics Study Site

Meridian, ID United States
  Connect »

Cara Therapeutics Study Site

Springfield, MA United States
  Connect »

Cara Therapeutics Study Site

Roseville, MI United States
  Connect »

Cara Therapeutics Study Site

Kansas City, MO United States
  Connect »

Cara Therapeutics Study Site

Albuquerque, NM United States
  Connect »

Cara Therapeutics Study Site

Ridgewood, NY United States
  Connect »

Cara Therapeutics Study Site

Winston-Salem, NC United States
  Connect »

Cara Therapeutics Study Site

Bethlehem, PA United States
  Connect »

Cara Therapeutics Study Site

Knoxville, TN United States
  Connect »

Cara Therapeutics Study Site

San Antonio, TX United States
  Connect »

Cara Therapeutics Study Site

Saint George, UT United States
  Connect »

Cara Therapeutics Study Site

Wauwatosa, WI United States
  Connect »

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.