Safety and Efficacy of Efavaleukin Alfa in Subjects With Steroid Refractory Chronic Graft Versus Host Disease

  • STATUS
    Recruiting
  • End date
    Feb 18, 2026
  • participants needed
    130
  • sponsor
    Amgen
Updated on 12 June 2021
Investigator
Amgen Call Center
Primary Contact
Research Site (9.5 mi away) Contact
+28 other location

Summary

Phase 1b: To evaluate the safety and tolerability of multiple ascending doses of efavaleukin alfa in subjects with steroid refractory chronic graft versus host disease (cGVHD).

Phase 2: To evaluate the efficacy of efavaleukin alfa in subjects with steroid refractory cGVHD as measured by overall response rate (ORR) at 16 weeks according to the 2014 cGVHD NIH Consensus Criteria.

Details
Condition Chronic Graft Versus Host Disease cGVHD
Treatment AMG 592, Efavaleukin Alfa
Clinical Study IdentifierNCT03422627
SponsorAmgen
Last Modified on12 June 2021

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