Aging Program Project Grant 6 (PPG6)

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    Northwestern University
Updated on 1 December 2022
Accepts healthy volunteers

Summary

This study aims to enhance circadian signals to improve cardiometabolic functions in older adults though meal timing interventions and melatonin supplements. Cardiometabolic disease (CMD) is prevalent among older adults, but despite vigorous research to prevent it, it remains on of the greatest public health challenges. Previous research has shown that extended overnight fasting and melatonin supplements may enhance circadian signals which in turn would enhance cardiometabolic function in older adults.

This study will place subjects in one of four intervention groups, 1) Meal timing + Melatonin, 2) Meal timing + Placebo, 3) Melatonin, or 4) Placebo in order test out the effects of meal timing and melatonin both separately and together and cardio metabolic functions. The study will explore the effects of these interventions in acute-based setting and extended-based settings. This will allow us to test out the hypotheses of the study that meal timing can improve amplitude of circadian signals and improve cardiometabolic functions and sleep quality as well as melatonin improving cardiometabolic function and sleep quality. Finally, we will determine if the the addition of melatonin will further enhance the effects of the meal timing intervention for improving cardiometabolic function and sleep.

Details
Condition Improving Cardiometabolic Outcomes in Older Adults
Treatment placebos, Melatonin 3 mg, Meal timing, Meal timing, Non-Meal timing, Melatonin 1 mg
Clinical Study IdentifierNCT03490825
SponsorNorthwestern University
Last Modified on1 December 2022

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