Last updated on March 2018

Effects of Yangxinshi Pills on the Exercise Tolerance of the Patients With Coronary Heart Disease

Brief description of study

Compared with conventional treatment of the coronary heart disease,the aim of the research is to find out if the addition of Yangxinshi pills on the basis of conventional treatment can improve exercise tolerance of patients with coronary heart disease, improve quality of life or restore social function and mental health

Detailed Study Description

90 outpatients with clear diagnosis of coronary heart diseases will be recruited in the trial and randomized into two group.

One group are treated with Yangxinshi pills (provided by Qingdao Growtful Pharmaceutical Co., Ltd.) plus conventional medicine, the other group are treated with placebo plus conventional medicine.

The primary end point is VO2max measured by cardiopulmonary exercise test after 3 months of treatment.

The secondary endpoint is:

  1. Mets, Anaerobic thresholdATmeasured by cardiopulmonary exercise test
  2. Changes of other composite indicators of treadmill exercise test or cardiopulmonary exercise test
  3. The maximum walking distance of 6-minute walk test;
  4. Changes of Seattle Angina Questionnaire;
  5. Hamilton Depression Scale/ Hamilton Anxiety Scale.

The safety evaluation criteria is:

  1. Adverse event and serious adverse event;
  2. Vital signs;
  3. Resting 12 lead ECG;
  4. Blood routine examination , urine routine examinationliver and renal function examination(ASTALTBUNCr).

Clinical Study Identifier: NCT03478332

Contact Investigators or Research Sites near you

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Xiaoping Meng, Doctor

Changchun Traditional Medicine University Affiliated Hospital
Chang Chun, China
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Recruitment Status: Open

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