Last updated on March 2018

High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Carotid Artery Stenosis
  • Age: Between 40 - 90 Years
  • Gender: Male or Female

Inclusion Criteria:

  • 50% stenosis of internal carotid artery in symptomatic patients; or 70% stenosis of internal carotid artery in asymptomatic patients
  • received statin therapy for 2weeks before inclusion

Exclusion Criteria:

  • nonatherosclerotic carotid disease (dissection, radiation-induced stenosis)
  • received endovascular procedure within 30 days before inclusion
  • CAS during the procedure of urgent endovascular therapy for acute ischaemic stroke
  • need for oral anticoagulant therapy
  • high risk of bleeding or contraindications to antiplatelet therapy (eg: platelet count <70 X 109/L)
  • active hepatic disease or hepatic dysfunction, or aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 1.5 upper normal limit
  • myopathy or increased creatine kinase (CK) > 2 upper normal limit
  • renal failure with serum creatinine (Scr) > 3 mg/dl or 264mol/L
  • unable to undergo MRI because of claustrophobia or pacemaker
  • pregnancy, lactation, or child bearing potential women without any effective contraception

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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