Last updated on November 2019

A Study of Ipatasertib in Combination With Paclitaxel as a Treatment for Participants With PIK3CA/AKT1/PTEN-Altered Locally Advanced or Metastatic Triple-Negative Breast Cancer or Hormone Receptor-Positive HER2-Negative Breast Cancer


Brief description of study

This study will evaluate the efficacy of ipatasertib + paclitaxel versus placebo + paclitaxel in participants with histologically confirmed, locally advanced or metastatic triple-negative breast cancer (TNBC) and in participants with locally advanced or metastatic hormone receptor positive (HR+)/ human epidermal growth factor receptor 2 negative (HER2) breast adenocarcinoma who are not suitable for endocrine therapy.

Clinical Study Identifier: NCT03337724

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UCSD Moores Cancer Center

La Jolla, CA United States
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Kaiser Permanente - Oakland

Oakland, CA United States
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Emad Ibrahim, Md, Inc

Redlands, CA United States
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Kaiser Permanente - Roseville

Roseville, CA United States
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San Leandro, CA United States
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Santa Clara, CA United States
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South San Francisco, CA United States
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Kaiser Permanente - Vallejo

Vallejo, CA United States
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K. Permanente - Walnut Creek

Walnut Creek, CA United States
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Memorial Regional Hospital

Hollywood, FL United States
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Memorial Hospital West

Pembroke Pines, FL United States
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University of Maryland

Baltimore, MD United States
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Mercy Medical Center

Baltimore, MD United States
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Memorial Sloan Kettering

New York, NY United States
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Mid Ohio Onc Hematology Inc

Columbus, OH United States
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West Clinic

Germantown, TN United States
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Brig Cancer Care

Knoxville, TN United States
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Texas Oncology, P.A.

Dallas, TX United States
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Clinica CIMCA

San Jose, Costa Rica
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ICM; Medecine B3

Montpellier cedex 5, France
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National Cancer Center

Gyeonggi-do, Korea, Republic of
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Clinical Hospital; Oncology Department

Bitola, Macedonia, The Former Yugoslav Republic of
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Moscow City Oncology Hospital #62

Moscovskaya Oblast, Russian Federation
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Velindre Cancer Centre

Cardiff, United Kingdom
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Royal Stoke University Hospital

Stoke on Trent, United Kingdom
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Beijing Hospital

Beijing City, China
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Inha University Hospital

Incheon, Korea, Republic of
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Samsung Medical Center

Seoul, Korea, Republic of
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USC Norris Cancer Center

Los Angeles, CA United States
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UCSF Comprehensive Cancer Ctr

San Francisco, CA United States
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Oncology Consultants PA

Houston, TX United States
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Hospital Britanico

Ciudad Autonoma Bs As, Argentina
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Parkland Hospital

Dallas, TX United States
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The Oncology Center

Durban, South Africa
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Hospital Provincial de Castellon; Servicio de Oncologia

Castellon DE LA Plana/castello DE LA Plana, Spain
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Derriford Hospital

Plymouth, United Kingdom
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