Improving Cognition Via Exercise in Schizophrenia

  • STATUS
    Recruiting
  • days left to enroll
    73
  • participants needed
    200
  • sponsor
    Icahn School of Medicine at Mount Sinai
Updated on 20 June 2022

Summary

People with schizophrenia display a broad range of cognitive impairments that have been identified as major determinants of poor functioning and disability. Also, people with schizophrenia are at increased risk for suicide, with approximately 40-50% of individuals attempting to take their own lives during their lifetime. The goal of the proposed study is to examine the impact of remote exercise training on cognition, suicide risk, daily functioning, and biomarkers of cognitive change and suicidality in people with schizophrenia.

Description

The goal of the proposed study is to examine the impact of remote exercise training on cognitive functioning in people with schizophrenia. People with schizophrenia display a broad range of cognitive impairments that have been identified as major determinants of poor functional outcome and disability, thus representing an important public health concern and a target for interventions. At present, available treatments offer only minimal to limited benefits to ameliorate these deficits. Extensive animal and human research literatures converge in supporting the positive influence of aerobic exercise training on cognitive functioning. Preliminary data indicate that aerobic exercise training is effective in improving cognitive functioning in people with schizophrenia. However, previous studies employed small samples, focused on a single or limited range of cognitive domains, and/or collected insufficient information on daily functioning or putative biomarkers underlying cognitive change. Supported by supplement funding from NIMH, the goal of the proposed study is also to explore the impact of remote exercise training on suicide risk in individuals with schizophrenia. People with schizophrenia are at increased risk for suicide, with approximately 40-50% of individuals attempting to take their own lives during their lifetime, and an estimated 5-10% actually being successful in completing suicide. This highly elevated risk represents a serious public health concern and an important target for interventions. However, available treatments offer only minimal to limited benefits to ameliorate this risk. Extensive animal and human research literatures converge in supporting the positive influence of AE training on a number of predictors of suicide risk including depressed mood, sleep difficulties, and poor cognition. Yet, at present there are no studies directly examining the impact of AE on suicide risk in this population.

Details
Condition Schizophrenia and Related Disorders
Treatment Aerobic Exercise, Stretching and toning exercise
Clinical Study IdentifierNCT03270098
SponsorIcahn School of Medicine at Mount Sinai
Last Modified on20 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

A DSM-V diagnosis of schizophrenia, schizoaffective, or schizophreniform disorder
Age 18-55 years
Taking antipsychotic medication for at least 8 weeks and on current doses for 4 weeks, and/or injectable depot antipsychotics with no change in the last 3 months
Capacity to understand all the potential risks and benefits of the study
Medically cleared by a physician to take part in VO2max tests and aerobic exercise training or stretching-and-toning exercise training

Exclusion Criteria

A DSM-V diagnosis of alcohol/substance abuse (except nicotine) within the last month or a diagnosis of alcohol/substance dependence (except nicotine) within the last 6 months
Initiation of anti-depressants, mood stabilizers, or other medications known to impact cognition in previous 4 weeks or any change in doses during this period
History of seizures/head trauma with loss of consciousness (>10 minutes) resulting in cognitive sequelae
Significant clinical abnormalities in physical examination, lab assessments, or ECG
Neurological/medical conditions that could interfere with study participation (e.g., unstable cardiac disease, stuttering)
Body Mass Index (BMI) ≥ 40
Untreated hyper- or hypothyroidism
Being pregnant or nursing
Serious homicidal/suicidal risk (past 6 months)
Moderate" or more severe conceptual disorganization (PANSS≥4)
Poor English reading ability (WTAR<7)
Participation in a study with cognitive assessment in the past 3 months
Serious homicidal risk (past 6 months)
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