A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

  • STATUS
    Recruiting
  • End date
    Nov 5, 2021
  • participants needed
    631
  • sponsor
    Janssen Research & Development, LLC
Updated on 12 October 2020
Investigator
The Medical Research Network, LLC
Primary Contact
Friedrich-Alexander Universitaet Urologische Universitaetskl (8.7 mi away) Contact
+522 other location
renal function
carcinoma
growth factor
pembrolizumab
docetaxel
vinflunine
adjuvant chemotherapy
transitional cell carcinoma
advanced urothelial carcinoma
erdafitinib

Summary

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor receptor (FGFR) aberrations who have progressed after 1 or 2 prior treatments, at least 1 of which includes an anti-PD-(L) 1 agent (cohort 1) or 1 prior treatment not containing an anti-PD-(L) 1 agent (cohort 2).

Description

A study of erdafitinib versus standard of care, consisting of chemotherapy (docetaxel or vinflunine) or anti-PD-(L) 1 agent pembrolizumab, in participants with advanced urothelial cancer and selected FGFR aberrations who have progressed on or after 1 or 2 prior treatments, at least 1 of which includes an anti-PD-(L) 1 agent (cohort 1) or 1 prior treatment not containing an anti-PD-(L) 1 agent (cohort 2). It will consist of screening, treatment phase (from randomization until disease progression, intolerable toxicity, withdrawal of consent or decision by investigator to discontinue treatment, post-treatment followup (from end-of-treatment to participants death, withdraws consent, lost to follow-up, or end of study, whichever comes first). Efficacy, pharmacokinetics, biomarkers, patient reported outcomes, medical resource utilization and safety will be assessed.

Details
Treatment docetaxel, Pembrolizumab, Vinflunine, Erdafitinib, Fibroblast Growth Factor Receptor inhibitor Clinical Trial Assay (FGFRi CTA)
Clinical Study IdentifierNCT03390504
SponsorJanssen Research & Development, LLC
Last Modified on12 October 2020

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Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have Urothelial Cancer?
Histologic demonstration of transitional cell carcinoma of the urothelium. Minor components ( less than [<] 50 percent [%] overall) of variant histology such as glandular or squamous differentiation, or evolution to more aggressive phenotypes such as sarcomatoid or micropapillary change are acceptable
Metastatic or surgically unresectable urothelial cancer
Documented progression of disease, defined as any progression that requires a change in treatment, prior to randomization
Cohort 1: Prior treatment with an anti-PD-(L) 1 agent as monotherapy or as combination therapy; no more than 2 prior lines of systemic treatment. Cohort 2: No prior treatment with an anti-PD-(L) 1 agent; only 1 line of prior systemic treatment. Subjects who received neoadjuvant or adjuvant chemotherapy and showed disease progression within 12 months of the last dose are considered to have received systemic therapy in the metastatic setting
A woman of childbearing potential who is sexually active must have a negative pregnancy test (beta human chorionic gonadotropin [beta hCG]) at Screening (urine or serum)
Participants must meet appropriate molecular eligibility criteria
Eastern Cooperative Oncology Group (ECOG) performance status Grade 0, 1, or 2
Adequate bone marrow, liver, and renal function

Exclusion Criteria

Treatment with any other investigational agent or participation in another clinical study with therapeutic intent within 30 days prior to randomization
Active malignancies (that is, requiring treatment change in the last 24 months). The only allowed exceptions are: urothelial cancer, skin cancer treated within the last 24 months that is considered completely cured, localized prostate cancer with a gleason score of 6 (treated within the last 24 months or untreated and under surveillance) and localized prostate cancer with a gleason score of 3+4 that has been treated more than 6 months prior to full study screening and considered to have a very low risk of recurrence
Symptomatic central nervous system metastases
Received prior fibroblast growth factor receptor (FGFR) inhibitor treatment
Known allergies, hypersensitivity, or intolerance to erdafitinib or its excipients
Current central serous retinopathy (CSR) or retinal pigment epithelial detachment of any grade
History of uncontrolled cardiovascular disease
Impaired wound healing capacity defined as skin/decubitus ulcers, chronic leg ulcers, known gastric ulcers, or unhealed incisions
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