Last updated on April 2019

Healthy Overweight & Obese NO 00000-0000

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: *Healthy Patient Studies | Healthy Volunteers
  • Age: Between 22 - 55 Years
  • Gender: Male or Female

If you are able to answer “YES” to the following statements, you may qualify for this study.

  • I am a healthy adult who is overweight or has obesity and no significant medical conditions.
  • I am Male and between 22 and 55 years old.
  • I am Female and between 22 and 45 years old.
  • My BMI is between 27.0 and 39.9 kg/m2 (inclusive).
  • I do not smoke or use any tobacco or nicotine products.  I agree not to smoke for the duration of the study and to abide by the rules of the clinic, which is a non-smoking facility.
  • I have not participated in (nor am I currently participating in) any clinical research study of an approved or non-approved investigational medicinal product within 30 days before screening.
  • I am a Female with regular menstrual cycles (defined as 24-35 day cycles between 1st day of menses for the two most recent menstrual periods).
  • If Female, I am not pregnant or breastfeeding and I do not intend to become pregnant.
  • If Female, I am not post-menopausal.
  • If Female, I am either surgically sterile by tubal ligation, or I agree to use a non-hormonal intrauterine device or diaphragm/cervical cap with spermicide in combination with condom for male partner(s).
  • If Female, I have not used hormonal contraceptives (oral contraceptives, implant or hormonal intrauterine device) within 3 months before screening.
  • If Male, I have had a vasectomy, or, I agree to use a condom with spermicidal foam/gel/cream combined with an approved contraceptive method if my partner is capable of becoming pregnant (e.g., implants, injectables, oral contraceptives, intrauterine devices, diaphragm, or cervical cap with spermicide).
  • If Male, I agree not to donate sperm from screening to 90 days after last dose of study drug.
  • I am able to communicate effectively in English with the study personnel.
  • I do not anticipate a change in lifestyle (e.g., eating, exercise or sleeping pattern) during the study.
  • I do not have a risk of atherosclerotic cardiovascular disease (NOTE: for subjects age 40+).
  • I do not have a history or presence of any cardiovascular disease including stable and unstable angina, myocardial infarction, transient ischaemic attack, stroke, cardiac decompensation, arrhythmias and conduction disorders.
  • I do not have a history or presence of bone disease or an increased risk of bone fracture.
  • I do not have a history or presence of cancer within the last 5 years prior to screening. (NOTE: Except for cured basal and squamous cell skin cancer and in-situ carcinomas.).
  • I do not have a history or presence of sleep apnea.
  • I do not have any special diet requirements and I am willing to eat the food provided while on-site and overnight stays.
  • I have not had any prior obesity surgery and I do not have a gastrointestinal implant.
  • I have not had a clinically significant weight change (e.g., ≥5% change), I have not dieted within 90 days prior to screening, and I am not participating in an organized weight reduction program.
  • I do not have any history of psychiatric disorders (e.g., schizophrenia, bipolar disorder, eating disorders, depression or anxiety).
  • I have not taken any prescription or nonprescription medications, herbal products, or non-routine vitamins within 2 weeks prior to screening. (NOTE: Mild painkillers are allowed until 24 hours before screening).
  • I do not have a history of alcohol abuse, within 12 months of screening (e.g. more than 7 units/weekly for females and more than 14 units/weekly for males).
  • I do not have a history of drug abuse/chemical substance abuse within 12 months before screening.
  • I have not donated blood, donated plasma in the last 60 days or had numerous blood draws within the past 30 days before screening.
  • I do not have a history of any severe or life-threatening allergies or a history of anaphylactic reactions (e.g., food or medications or latex).
  • I have not had problems having blood drawn in either arm, venous access or finger pricks.

Recruitment Status: Closed

Brief Description Eligibility Contact Research Team

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