Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction(ThyroHeart-AMI)

    Not Recruiting
  • participants needed
  • sponsor
    Chinese Academy of Medical Sciences, Fuwai Hospital
Updated on 22 January 2021
ejection fraction
myocardial infarction
percutaneous coronary intervention
acute myocardial infarction
thyroid hormones


Based on accumulating evidences showing that hypothyroid status is associated with poor prognosis among acute myocardial infarction (AMI) patients, the study is designed to evaluate whether replacement treatment with levothyroxine could have beneficial effects on patients with AMI and hypothyroidism. This is a multicenter prospective computerized-randomized trial stratified by ejection fraction with a 1:1 ratio to levothyroxine group or standard therapy group.


The primary hypothesis is that reversing the hypothyroid status with levothyroxine on top of standard therapy for AMI is safe and has beneficial effects on cardiac function, myocardial perfusion/metabolism and myocardial fibrosis.

Condition Myocardial Infarction, Hypothyroidism
Treatment levothyroxine
Clinical Study IdentifierNCT02512978
SponsorChinese Academy of Medical Sciences, Fuwai Hospital
Last Modified on22 January 2021

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