Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG

  • STATUS
    Recruiting
  • End date
    Oct 16, 2025
  • participants needed
    142
  • sponsor
    Novartis Pharmaceuticals
Updated on 12 May 2021
vincristine
measurable disease
BRAF
progressive disease
carboplatin
malignant glioma
low grade glioma
trametinib
dabrafenib

Summary

The purpose of this study is to investigate the activity of dabrafenib in combination with trametinib in children and adolescent patients with BRAF V600 mutation positive low grade glioma or relapsed or refractory high grade glioma.

Details
Condition Ganglioneuroma, Oligodendroglioma, Astrocytoma, Glioma, Glioblastoma Multiforme, Malignant neoplasm of brain, Ganglioglioma, Neurocytoma, Brain Tumor (Pediatric), Pleomorphic Xanthoastrocytoma, Anaplastic Ganglioglioma, Giant Cell Astrocytoma, Anaplastic Pleomorphic Xanthoastrocytoma, Angiocentric Glioma, Chordoid Glioma of Third Ventricle, Dysplastic Gangliocytoma of Cerebrellum, Desmoplastic Infantile Astrocytoma and Ganglioglioma, Papillary Glioneuronal Tumor, Rosette-forming Glioneurona Tumor, Extraventricular Neurocytoma, Cerebellar Iponeurocytoma, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Brain Cancer, Gliomas, Brain Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, anaplastic astrocytoma, anaplastic oligodendroglioma, glioblastoma, gangliogliomas, astrocytoma, anaplastic, oligodendroglioma, anaplastic, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor, Rosette-forming Glioneurona Tumor
Treatment Dabrafenib, Trametinib, Carboplatin with vincristine
Clinical Study IdentifierNCT02684058
SponsorNovartis Pharmaceuticals
Last Modified on12 May 2021

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