Last updated on June 2019

Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Hypertension | Autonomic nervous system disorders | ORTHOSTATIC HYPOTENSION
  • Age: Between 18 - 80 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Control population: Healthy males or females between the ages of 18-80.
  • Patient population: Males or females who have been previously diagnosed with Neurogenic Orthostatic Hypotension.

Exclusion Criteria:

Patient population:

  1. Medical therapies or medications which could interfere with testing of autonomic function.
  2. Clinically significant heart disease.
  3. Presence of unrelated nerve damage in the peripheral nervous system.
  4. Pregnant or breast feeding females.
  5. The presence of failure of other organ systems or systemic illness that can affect autonomic function or your ability to cooperate. These include dementia, heart failure, kidney or liver disease, severe anemia, alcoholism, any new and abnormal cell growth identified as malignant, hypothyroidism, surgical procedures where the nerves of the sympathetic nervous system have been cut, or cerebrovascular disease.

Exclusion criteria for monitoring the effects of melatonin

  1. All the above PLUS No lying/night time hypertension as determined by 24-hour blood pressure monitoring

Exclusion criteria for healthy controls:

  1. Presence of ANY autonomic dysfunction
  2. Medical therapies or medications which could interfere with testing of autonomic function.
  3. Clinically significant heart disease.
  4. Presence of ANY nerve damage in the peripheral nervous system.
  5. Pregnant or breast feeding females.
  6. The presence of failure of other organ systems or systemic illness that can affect autonomic function or your ability to cooperate. These include dementia, heart failure, kidney or liver disease, severe anemia, alcoholism, any new and abnormal cell growth identified as malignant, hypothyroidism, surgical procedures where the nerves of the sympathetic nervous system have been cut, or cerebrovascular disease.

Recruitment Status: Closed


Brief Description Eligibility Contact Research Team


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