Last updated on January 2019

Safety and Efficacy of Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension

Brief description of study

The objective of this randomized control trial is to gain clinical insight on the use of pulmonary artery denervation (PADN) for the treatment of pulmonary arterial hypertension (PAH). The primary objective is to assess effectiveness and safety of PADN for the treatment of PAH.

Detailed Study Description

The current study is designed as a multicenter, randomized and prospective study aiming to compare the change in 6-minute walk distance (6MWD) of PADN on PAH patients. Based on the previous studies, the 6MWD was 1324 m after 6-month treatment using target drugs. And our previous data showed that 6MWD at 6-month after PADN procedure was 6585 m. As a result, a total of 128 PAH patients was required, with 64 patients/per group at a ratio of 1:1 randomization.

Clinical Study Identifier: NCT03282266

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Nanjing First Hospital

Nanjing, China
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