Last updated on September 2020

A Study of Local Therapy for the Treatment of Brain Metastases From HER2 Positive Breast Cancer

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Breast Cancer
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Age 18 years or older
  • Metastatic HER2 positive breast cancer
  • 1-5 synchronous brain metastases
  • At least one metastases requiring treatment
  • Maximum volume of any single PTV <10cm3
  • Summated volume of all lesions to be treated with SRS is < 15cm3. If a lesion is too small for treatment and will be observed, then its volume is not included in this summation
  • ECOG 0-2
  • Absent or stable extracranial disease or active extracranial disease that is likely to be controlled with further HER-2 targeted therapy
  • Receiving systemic HER2 targeted therapy, or planned to receive within 4 weeks of completion of brain metastasis treatment
  • Able to undergo MRI scanning

Exclusion Criteria:

  • Previous treatment to the target brain metastases (excluding surgery within 6 weeks of registration)
  • Previous whole brain radiotherapy (WBRT)
  • Any brain metastasis that is greater than 30mm in size and unable to be resected
  • Leptomeningeal disease
  • Pregnant or breastfeeding

Recruitment Status: Closed

Brief Description Eligibility Contact Research Team

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