Last updated on December 2019

Endogenous Modulation and Central Sensitization in New Daily Persistent Headache ( NDPH ) in Children

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: New Daily Persistent Headache (NDPH)
  • Age: Between 10 - 17 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Patients meeting clinical International Classification of Headache Disorders (ICHD-3 )classification for NDPH 2) Age 10-17 years, all sexes, races, and ethnicities 3) English speaking 4) Able to wean off headache prophylactic medication 2 weeks prior to start of Naltrexone trial (patient will still be able to use abortive medication throughout the duration of the study) 5) On stable psychotropic medication for mild anxiety and/or mood disturbance for 2 weeks


Exclusion Criteria:

  1. Children and adolescents with significant chronic medical illness: Central Nervous systen (secondary headache disorder other than mild traumatic brain injury); Cardiac, Pulmonary other than stable asthma, Metabolic, Renal, Hepatic 2) Significant psychiatric disorder, such as major depression, somatization disorder, and psychosis 3) Pregnancy 4) Intellectual delay or cognitive limitations precluding completion of questionnaires or following instructions.


Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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