Alpha MSH in Ocular Disease

  • STATUS
    Recruiting
  • End date
    Dec 30, 2021
  • participants needed
    60
  • sponsor
    Duke University
Updated on 27 January 2021

Summary

The purpose of this study is gain a better understanding of a molecule called alpha melanocyte stimulating hormone (alpha MSH) and its potential role in your retinal disease. Alpha MSH has been shown to have an important role in the regulation of ocular immunity in animal models of inflammatory retinal diseases and retinal dystrophies, and there may be a protective effect of alpha MSH. By studying the levels of alpha MSH in your eye we may better understand its role in advanced dry macular degeneration. By studying the levels of this molecule we hope to better understand if it may be a good target for future treatment.

Description

A small amount (0.1 mL) of aqueous humor would be removed from the study eye in the clinic setting. This sample will be processed and then sent off for measurement of alpha MSH levels.

Details
Condition Advanced Dry Macular Degeneration
Treatment Alpha MSH assay
Clinical Study IdentifierNCT03451578
SponsorDuke University
Last Modified on27 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

years or older
diagnosis of advanced dry macular degeneration with foveal geographic atrophy
limited vision or blindness (20/100 or worse) in that eye
pseudophakia (prior cataract surgery in that eye)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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