Assessment of Intellectual Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Their Pregnancy

  • STATUS
    Not Recruiting
  • participants needed
    252
  • sponsor
    University Hospital, Angers
Updated on 22 January 2021

Summary

  1. MAIN OBJECTIVE :

To assess the consequences of a maternal hyperthyrod during pregnancy on intellectual development of the child from 6 to 9 years

2. SECONDARY OBJECTIVES :

  1. To assess the consequences of a maternal hyperthyrod during pregnancy on the capacities of attention, learning process and the degree of hyperactivity of the child from 6 to 9 years.
  2. To study if it exist differences of intellectual development, capacities of attention, learning process, and degree of hyperactivity in the child from 6 to 9 years, born to hyperthyroid mother during pregnancy, according to:
    • the etiology of the maternal hyperthyrod (transitory gestation hyperthyroid versus disease of Basedow),
    • the use or not of a anti-thyroid treatment,
    • the rate of TSH nonatal (measured with the blotter by tracking with J3 at all the new born ones).

Description

  1. INCLUSION CRITERIA :
    • Old from 6 to 9 years included
    • Age of gestation between 37 and <41 weeks of amenorrhoea
    • Born from a mono-foetale pregnancy
    • Euthyrod at the time of the entry in the study
    • Provided education for at the elementary school on a level adapted to its age 2. NON INCLUSION CRITERIA :
    • Presenting a congenital hypothyrod or a known thyroid dysfonction at the time of the entry in the study
    • Carrier of a chronic pathology (organic or psychological) or malformative severe
    • Presenting an antecedent of Deficit of the Attention-Hyperactivity to the 1st degree 3. EXCLUSION CRITERIA :
      • Discovered of a thyroid dysfonction at the time of the entry in the study 4. STRATEGIES / PROCEDURES :

Multicentric, comparative study of a troop of child born to hyperthyrod mothers during pregnancy (children exposed to the maternal hyperthyrod) and children born to euthyrod mothers during pregnancy (nonexposed children with the maternal hyperthyrod).

  • 1st part of the study: Retrospective analyze of the files of symptomatic hyperthyroid mothers during pregnancy.
  • 2nd part of the study: Assessment of intellectual development, capacities of attention, learning process and degree of hyperactivity of the children between 6 and 9 years. The exposed children (born to hyperthyrod mothers during pregnancy) will be compared with nonexposed children (born to euthyrod mothers during pregnancy).

Details
Condition Hyperthyroid
Treatment Assessment of intellectual development, capacities of attention, learning process and degree of hyperactivity of the children between 6 and 9 years.
Clinical Study IdentifierNCT01779817
SponsorUniversity Hospital, Angers
Last Modified on22 January 2021

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