Last updated on June 2018

Assessment of Intellectual Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Their Pregnancy


Brief description of study

  1. MAIN OBJECTIVE :

To assess the consequences of a maternal hyperthyrod during pregnancy on intellectual development of the child from 6 to 9 years

2. SECONDARY OBJECTIVES :

  1. To assess the consequences of a maternal hyperthyrod during pregnancy on the capacities of attention, learning process and the degree of hyperactivity of the child from 6 to 9 years.
  2. To study if it exist differences of intellectual development, capacities of attention, learning process, and degree of hyperactivity in the child from 6 to 9 years, born to hyperthyroid mother during pregnancy, according to:
    • the etiology of the maternal hyperthyrod (transitory gestation hyperthyroid versus disease of Basedow),
    • the use or not of a anti-thyroid treatment,
    • the rate of TSH nonatal (measured with the blotter by tracking with J3 at all the new born ones).

Detailed Study Description

  1. INCLUSION CRITERIA :
    • Old from 6 to 9 years included
    • Age of gestation between 37 and <41 weeks of amenorrhoea
    • Born from a mono-foetale pregnancy
    • Euthyrod at the time of the entry in the study
    • Provided education for at the elementary school on a level adapted to its age 2. NON INCLUSION CRITERIA :
    • Presenting a congenital hypothyrod or a known thyroid dysfonction at the time of the entry in the study
    • Carrier of a chronic pathology (organic or psychological) or malformative severe
    • Presenting an antecedent of Deficit of the Attention-Hyperactivity to the 1st degree 3. EXCLUSION CRITERIA :
      • Discovered of a thyroid dysfonction at the time of the entry in the study 4. STRATEGIES / PROCEDURES :

Multicentric, comparative study of a troop of child born to hyperthyrod mothers during pregnancy (children exposed to the maternal hyperthyrod) and children born to euthyrod mothers during pregnancy (nonexposed children with the maternal hyperthyrod).

  • 1st part of the study: Retrospective analyze of the files of symptomatic hyperthyroid mothers during pregnancy.
  • 2nd part of the study: Assessment of intellectual development, capacities of attention, learning process and degree of hyperactivity of the children between 6 and 9 years. The exposed children (born to hyperthyrod mothers during pregnancy) will be compared with nonexposed children (born to euthyrod mothers during pregnancy).

Clinical Study Identifier: NCT01779817

Find a site near you

Start Over

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.