Last updated on February 2018

IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Autoimmune Encephalitis | Psychosis
  • Age: Between 18 - 70 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Acute psychosis >2 weeks, either first episode or relapse after remission (remission defined as PANSS3 on PANSS items P1, G9, P3, P2, G5, N1, N4, N6 for previous 6 months)
  • Serum or CSF neuronal membrane autoantibodies at pathological levels (including NMDAR, LGI1 and other)
  • PANSS 4 on P1, G9, P3, P2, G5, N1, N4, N6.

Exclusion Criteria:

  • Current episode of psychosis greater than 24 months duration
  • Co-existing severe neurological disease
  • Evidence of current acute encephalopathy
  • Hepatitis or HIV infection, pregnancy
  • Contraindications to any trial drug
  • Concurrent enrolment in another CTIMP

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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