Last updated on July 2020

Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC


Brief description of study

The study is a multi-center, un-blinded, randomized control study of subjects with locally advanced pancreatic adenocarcinoma which is unresectable.

Detailed Study Description

All subjects will receive induction therapy of IV gemcitabine plus nab-paclitaxel, as well as radiation therapy for approximately four months. Subjects who remain eligible will then be randomized to receive either intra-arterial chemotherapy with gemcitabine; or to continue gemcitabine plus nab-paclitaxel. Subjects will receive the randomized treatments for up to 16 weeks or until progression. Both groups will receive either IV gemcitabine and nab-paclitaxel or oral capecitabine following the 16 week treatment course until disease progression at the discretion of the Investigator.

Clinical Study Identifier: NCT03257033

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Montefiore Hospital

Bronx, NY United States
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East Carolina University

Greenville, NC United States
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Ochsner Clinic Foundation

New Orleans, LA United States
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Georgetown University

Washington, WA United States
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21st Century Oncology

Fort Myers, FL United States
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Miami Cancer Institute

Miami, FL United States
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Medstar Franklin Square

Baltimore, MD United States
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Moffitt Cancer Center

Tampa, FL United States
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VA Loma Linda Healthcare System

Loma Linda, CA United States
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ASCLEPES Research Centers

Weeki Wachee, FL United States
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UZ Antwerp

Edegem, Belgium
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UZ Gent

Gent, Belgium
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Jolimont Hospital

La Louvière, Belgium
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AZ Delta

Roeselare, Belgium
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Jolimont Hospital

La Louvière, Belgium
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Jolimont Hospital

La Louvière, Belgium
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Jolimont Hospital

La Louvière, Belgium
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Jolimont Hospital

La Louvière, Belgium
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Jolimont Hospital

La Louvière, Belgium
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Jolimont Hospital

La Louvière, Belgium
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Jolimont Hospital

La Louvière, Belgium
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Jolimont Hospital

La Louvière, Belgium
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Jolimont Hospital

La Louvière, Belgium
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Jolimont Hospital

La Louvière, Belgium
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Jolimont Hospital

La Louvière, Belgium
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LSU Health Shreveport

Shreveport, LA United States
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Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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