Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC (TIGeR-PaC)
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- STATUS
- Recruiting
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- End date
- Sep 10, 2023
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- participants needed
- 320
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- sponsor
- RenovoRx
Summary
The study is a multi-center, un-blinded, randomized control study of subjects with locally advanced pancreatic adenocarcinoma which is unresectable.
Description
All subjects will receive induction therapy of IV gemcitabine plus nab-paclitaxel, as well as radiation therapy for approximately four months. Subjects who remain eligible will then be randomized to receive either intra-arterial chemotherapy with gemcitabine; or to continue gemcitabine plus nab-paclitaxel. Subjects will receive the randomized treatments for up to 16 weeks or until progression. Both groups will receive either IV gemcitabine and nab-paclitaxel or oral capecitabine following the 16 week treatment course until disease progression at the discretion of the Investigator.
Details
| Condition | Locally Advanced Pancreatic Cancer |
|---|---|
| Treatment | Gemcitabine, Nab-paclitaxel, RenovoCath |
| Clinical Study Identifier | NCT03257033 |
| Sponsor | RenovoRx |
| Last Modified on | 10 March 2022 |
Eligibility
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