Pulmonary Rehabilitation in End-Stage Liver Disease

  • STATUS
    Recruiting
  • End date
    Dec 30, 2022
  • participants needed
    50
  • sponsor
    Mayo Clinic
Updated on 26 February 2022
liver disease
liver transplant

Summary

The purpose of this study is to assess the impact of exercise on sarcopenia and frailty. The exercise that will be performed in this study will include either pulmonary rehabilitation or a formal home based video strengthening program

Description

Participants will be randomized into two groups. The Pulmonary Rehabilitation group will undergo exercise under a supervised setting for a total duration of 12 weeks. Patients will perform endurance (treadmill or cycle ergometer), strength (weight resistance) and flexibility training twice a week for a period of an hour per session. Exercises will be supervised by physiotherapists or exercise physiologists. Compliance and performance will be monitored by the trainer. They will receive a pedometer for home use. The Home based program group will perform REST for 10 minutes daily, increasing to 20 minutes daily, after the second week, in their home environment. The total duration of the intervention will be 12 weeks. Patients will be provided with pedometers, REST video and binder, with instructions on how to perform exercises, and resistance bands.

Details
Condition End Stage Liver Disease
Treatment Home Based Exercise, Pulmonary Rehabilitation Exercise
Clinical Study IdentifierNCT03266575
SponsorMayo Clinic
Last Modified on26 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

wait listed for liver transplantation with poor 6 MWT

Exclusion Criteria

age < 18 years
recent hospitalization (within 14 days) due to decompensation, variceal bleeding in the previous 1 month
large esophageal varices without primary prophylaxis
active excessive alcohol intake (in the previous 3 months)
current overt uncontrolled hepatic encephalopathy
hepatopulmonary syndrome with uncontrolled hypoxia
portopulmonary hypertension
inability to perform exercise
marked symptomatic comorbidities (cardiac, pulmonary, renal)
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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