Pulmonary Rehabilitation in End-Stage Liver Disease

  • End date
    Dec 30, 2022
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 26 February 2022
liver disease
liver transplant


The purpose of this study is to assess the impact of exercise on sarcopenia and frailty. The exercise that will be performed in this study will include either pulmonary rehabilitation or a formal home based video strengthening program


Participants will be randomized into two groups. The Pulmonary Rehabilitation group will undergo exercise under a supervised setting for a total duration of 12 weeks. Patients will perform endurance (treadmill or cycle ergometer), strength (weight resistance) and flexibility training twice a week for a period of an hour per session. Exercises will be supervised by physiotherapists or exercise physiologists. Compliance and performance will be monitored by the trainer. They will receive a pedometer for home use. The Home based program group will perform REST for 10 minutes daily, increasing to 20 minutes daily, after the second week, in their home environment. The total duration of the intervention will be 12 weeks. Patients will be provided with pedometers, REST video and binder, with instructions on how to perform exercises, and resistance bands.

Condition End Stage Liver Disease
Treatment Home Based Exercise, Pulmonary Rehabilitation Exercise
Clinical Study IdentifierNCT03266575
SponsorMayo Clinic
Last Modified on26 February 2022


Yes No Not Sure

Inclusion Criteria

wait listed for liver transplantation with poor 6 MWT

Exclusion Criteria

age < 18 years
recent hospitalization (within 14 days) due to decompensation, variceal bleeding in the previous 1 month
large esophageal varices without primary prophylaxis
active excessive alcohol intake (in the previous 3 months)
current overt uncontrolled hepatic encephalopathy
hepatopulmonary syndrome with uncontrolled hypoxia
portopulmonary hypertension
inability to perform exercise
marked symptomatic comorbidities (cardiac, pulmonary, renal)
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note