Contextual Associations During Episodic Recall of Everyday or Virtual Reality (BREAL)

  • End date
    Nov 11, 2023
  • participants needed
  • sponsor
    Hospices Civils de Lyon
Updated on 21 March 2022
Accepts healthy volunteers


The project is dedicated to development of new paradigms to investigate memory and attention in the rich and realistic environments. The investigator will use modern interactive digital technologies for encoding complex episodes either using mobile phone technology in everyday life or using a virtual reality life-like simulation.

He aims to characterize the role of the medial temporal lobe and prefrontal cortex during recall of naturalistic episodic experiences, using functional neuroimaging (fMRI) in healthy participants. The secondary aim is assess how the allocation of attention during memory encoding contribute to mechanisms of the subsequent recall. He will achieve this by monitoring gaze direction during encoding and by analyzing the retrieval data as a function of the elements that participants attended / fixated during encoding.

The protocol will involve, first, behavioral testing of memory performance with encoding in the real-life or in virtual reality, followed by the main hypothesis testing phase when fMRI will be used to measure brain activity during retrieval.

Condition Healthy Volunteers
Treatment Functional brain imaging without any contrast agent
Clinical Study IdentifierNCT03286387
SponsorHospices Civils de Lyon
Last Modified on21 March 2022


Yes No Not Sure

Inclusion Criteria

Possession a Smartphone compatible with GPS 3-rd generation and exploitation system Android 4.2 with user-activated geolocation (for mobile phone studies)
Able to navigate in virtual reality with a help of the keyboard (for virtual reality studies)
Not using glasses
All subjects will give their written consent for participation in the study
They will be right-handed
They will have French social coverage

Exclusion Criteria

Previous neurologic or psychiatric disease
Cognitive deficits restricting understanding of the tasks
Pregnant or breath-feeding women
Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights or liberty
Subjects currently participating in other study
Additional exclusion criteria for an fMRI recording
Neurologic, cardiac electrostimulation or defibrillator
Cardiac prostheses
Intracranial clips or clamps
Cerebrospinal fluid disorders
Metal particles in the eyes
Metal dental or articular prostheses
Diffusion pomp or other infusion system
Head tattoo , makeup, hair gel
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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