Safety and Efficacy of Pembrolizumab (MK-3475) in Combination With TS-1+Cisplatin or TS-1+Oxaliplatin as First Line Chemotherapy in Gastric Cancer (MK-3475-659/KEYNOTE-659)

  • STATUS
    Not Recruiting
  • participants needed
    90
  • sponsor
    Merck Sharp & Dohme Corp.
Updated on 9 June 2021
measurable disease
oxaliplatin
pembrolizumab
HER2
human epidermal growth factor
adenocarcinoma
erbb2
mk-3475

Summary

The purpose of this study is to estimate overall response rates (ORRs) of pembrolizumab + oxaliplatin + TS-1 and pembrolizumab + cisplatin + TS-1, as first-line treatment for gastric cancer in programmed death-ligand 1 (PD-L1) positive, human epidermal growth factor receptor 2 (HER2/neu)-negative participants with advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma.

Description

Approximately 45 participants will be assigned first to pembrolizumab + oxaliplatin + TS-1 combination therapy (Cohort 1), and then 45 participants will be assigned to pembrolizumab + cisplatin + TS-1 combination therapy (Cohort 2).

Details
Condition Gastric Cancer
Treatment cisplatin, Pembrolizumab, Oxaliplatin, TS-1
Clinical Study IdentifierNCT03382600
SponsorMerck Sharp & Dohme Corp.
Last Modified on9 June 2021

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