Opioid Free Anesthesia and Major Spine Surgery

  • STATUS
    Recruiting
  • participants needed
    48
  • sponsor
    Lebanese American University
Updated on 26 June 2022
anesthesia
dexmedetomidine
postoperative pain
ketamine
opioid
lidocaine
spine surgery

Summary

This study compares the intraoperative opioid free anesthesia approach in multilevel spine posterior instrumentation surgery to a conventional opioid-based anesthesia. Half of participants will receive opioid free anesthesia with dexmedetomidine, lidocaine and ketamine while the other half will receive opioid based anesthesia with fentanyl, remi-fentanyl and ketamine

Description

Opioid analgesics are commonly used in clinical practice for per and postoperative pain treatment. However their use is associated with a lot of undesirable effects. From this comes the idea of using opioid free anesthesia intra-operatively in an attempt to decrease opioids postoperative use and accordingly, their associated side effects.

Intravenous (IV) lidocaine has been found to have analgesic, antihyperalgesic, and anti-inflammatory properties. It was found to significantly improve postoperative pain, when its intraoperative use was compared with placebo .

Dexmedetomidine is a selective alpha-two adrenergic receptor agonist that has antinociceptive, analgesic, opioid sparing and sedative properties. Similar to lidocaine, dexmedetomidine was shown to lower postoperative pain, opioid consumption and accordingly, opioid related side effects.

Details
Condition Opioid Use, Postoperative Pain, Spine Disease
Treatment opioid free Anesthesia vs Opioid based Anesthesia
Clinical Study IdentifierNCT03417193
SponsorLebanese American University
Last Modified on26 June 2022

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