Impact of Preoperative Single Corticosteroid Flash on Morbidity After Colorectal Resection: Monocentric Prospective Pilot Study (CORTICOLON)

  • days left to enroll
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire Dijon
Updated on 26 February 2022


Complications due to infection after colorectal surgery are frequent, affecting up to 25% of patients. Infection increases mortality, lengthens hospital stays, increases costs and decreases long term survival for cancer patients. Perioperative inflammation leads to hypercatabolism, denutrition and immunosuppression, all of which are associated to postoperative infection. Data from various sources suggests that modulating perioperative inflammatory response through the injection of corticosteroids would benefit the patient by reducing the number of postoperative complications after major surgery. Pre- or perioperative intravenous administration of a single corticosteroid flash is a means of modulating systemic inflammation that has been suggested for numerous types of surgeries, including pancreatic surgery. The objective of this study is to assess whether a preoperative single corticosteroid flash (methylprednisolone: 20 mg/kg IV at anesthetic induction) reduces the risk of serious complications after elective colorectal surgery.

Condition Elective Colorectal Surgery
Treatment blood samples, injection of methylprednisolone at anesthetic induction
Clinical Study IdentifierNCT03437746
SponsorCentre Hospitalier Universitaire Dijon
Last Modified on26 February 2022


Yes No Not Sure

Inclusion Criteria

Adult patient
Patient undergoing elective colorectal surgery (diverticulitis, malignant or benign tumor, inflammatory intestinal disease, re-establishing continuity, endometriosis, or other)
Bowel continuity is restored immediately after surgery, with or without a protective stoma
Patient with proper understanding who has been informed about the study, and who has consented to being part of the study

Exclusion Criteria

Adult under guardianship
Patient who is not covered under the national health system
Women who are pregnant or breastfeeding
Colorectal resection with concomitant hyperthermic intraperitoneal chemotherapy
Patient under long term corticosteroid therapy
Preoperative natremia > 147 mmol/L
Hypokalemia (< 3,3 mmol/L)
Patient with a contraindication to Methylprednisolone Mylan
Active infection
Active viral disease (namely hepatitis, herpes, varicella, shingles)
A psychotic condition that is not currently treated with medication
Vaccination with a live vaccine or live attenuated within the last 3 months
Hypersensitivity to methylprednisolone or to any of the excipients found in Methylprednisolone Mylan
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note