Effects of Antirheumatic Treatment on Levels of Survivin in Rheumatoid Arthritis Patients

  • STATUS
    Recruiting
  • days left to enroll
    50
  • participants needed
    2500
  • sponsor
    Vastra Gotaland Region
Updated on 24 January 2021
methotrexate
tofacitinib
folate
sulfasalazine
abatacept
baricitinib
tocilizumab
antirheumatics

Summary

To validate the utility of survivin as a biomarker of pharmacological response to therapeutic intervention in rheumatoid arthritis patients.

Description

In a prospective observational study the investigators aim to study the ability of modern antirheumatic treatments to suppress levels of survivin in sera. Rheumatoid arthritis patients scheduled to start new pharmacological treatment will be followed for a period of 6 months. No intervention or influence on choice of treatment will be performed, the decision of new/other medication is entirely made by the patient and their rheumatologist. The study entails addition of survivin analyse (1 vial of sera) before and after start of new treatment. Data concerning survivin levels, disease activity and other clinical parameters before and after start of new treatment will also be analysed. The patients will leave sera for survivin analyse at baseline and 3 and 6 months after start of new treatment.

Details
Condition Rheumatoid Arthritis, Rheumatoid Arthritis (Pediatric)
Treatment methotrexate, Tocilizumab, Abatacept, Sulfasalazine, tofacitinib/baricitinib
Clinical Study IdentifierNCT03440892
SponsorVastra Gotaland Region
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients fulfilling the RA classification criteria according to the ACR/EULAR

Exclusion Criteria

Patients at stable/unchanged anti-rheumatic treatment
Other serious physical or mental illness
Lack of knowledge in Swedish making answering the questionnaires impossible
Clear my responses

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