ALzheimer and MUsic THerapy: Effects of Music Lessons on Brain Plasticity, Mood, and Quality of Life in Alzheimer Patients (ALMUTH)

  • End date
    Jun 21, 2023
  • participants needed
  • sponsor
    University of Bergen
Updated on 26 February 2022
alzheimer's disease
neurodegenerative disorders


Music has powerful effects on memory in patients with neurodegenerative diseases. However, although there is anecdotal evidence for beneficial effects of active music interventions in patients with Alzheimer's disease (AD), there is lack of high-quality research investigating this issue, and the cognitive, emotional, and social factors that contribute to potentially beneficial effects of music making in AD patients are largely unknown. In a randomised controlled intervention trial, a cohort of AD patients will undergo twelve months of music lessons specifically tailored for AD patients. Structural and functional magnetic resonance imaging (MRI) will be used to determine changes in brain age (as compared to two control groups), and voxel-based morphometry will be computed to determine contributions of different factors of the music intervention (cognitive, emotional, and social) to plastic changes of brain morphology, and a potential deceleration of brain atrophy. In addition, quality of life of patients. In cooperation with the Bergen municipality, and a strong network of national and international partners, the neurocognitive music therapy will be implemented, involving training of music therapists, and communication of results to patients, patient groups, and therapists.

Condition Alzheimer Disease, Mild Cognitive Impairment, MCI With Increased Risk for Alzheimer Disease
Treatment Training intervention, Music lessons
Clinical Study IdentifierNCT03444181
SponsorUniversity of Bergen
Last Modified on26 February 2022


Yes No Not Sure

Inclusion Criteria

Diagnosis of Alzheimer Disease
Living independently at home (not in a care home or similar aged care facility)
Able to complete questionnaires in Norwegian
Able to undergo MRI scans
Able to attend interventions and assessments in the area of Bergen, Norway
Has given informed consent

Exclusion Criteria

Hearing impairment that cannot be mended by hearing aids
Conditions that hinder MRI scans, such as claustrophobia or metal objects in body (e.g. pacemakers)
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