Last updated on July 2019

Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)


Brief description of study

This randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of gantenerumab versus placebo in participants with early (prodromal to mild) AD. All participants must show evidence of beta-amyloid pathology. Eligible participants will be randomized 1:1 to receive either subcutaneous (SC) injection of gantenerumab or placebo. The primary efficacy assessment will be performed at the end of the double blind period at week 104. Participants will then be offered to enter into an open-label extension (OLE). Participants not willing to go to the OLE will participate in a long term follow-up period for up to 50 weeks after the last gantenerumab dose.

Clinical Study Identifier: NCT03444870

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Center for Neurosciences

Tucson, AZ United States
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CITrials, Inc.

Bellflower, CA United States
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Excell Research

Oceanside, CA United States
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ASCLEPES Research Centers

Panorama City, CA United States
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CITrials, Inc.

Riverside, CA United States
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Sutter Medical Group, Neurology

Sacramento, CA United States
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Syrentis Clinical Research

Santa Ana, CA United States
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Upland Clinical Research

Upland, CA United States
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Bradenton Research Center

Bradenton, FL United States
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Clinical Research of South Florida

Coral Gables, FL United States
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Brain Matters Research, Inc.

Delray Beach, FL United States
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SIH Research

Kissimmee, FL United States
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Neuropsychiatric Research

Winfield, IL United States
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Galen Clinical Research

Chesterfield, MO United States
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NeuroCognitive Institute

Mount Arlington, NJ United States
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Richard H Weisler, MD

Raleigh, NC United States
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The Clinical Trial Center, LLC

Jenkintown, PA United States
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Abington Neurological Associates

Willow Grove, PA United States
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Coastal Neurology

Port Royal, SC United States
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Clinical Research Associates

Nashville, TN United States
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FutureSearch Trials, LP

Austin, TX United States
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Wasatch Clinical Research, LLC

Salt Lake City, UT United States
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UW Wisconsin-Madison

Madison, WI United States
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Neuro Trials Victoria

Noble Park, Australia
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CHU Angers

Angers, France
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Yuai Clinic

Kanagawa, Japan
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Samara Psychiatric Hospital

Samara, Russian Federation
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Llc Lion-Med

Voronezh, Russian Federation
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JEM Research LLC

Atlantis, FL United States
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Fort Wayne Neurological Center

Fort Wayne, IN United States
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UC Health Neurology

Dayton, OH United States
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University of Virginia

Charlottesville, VA United States
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Columbus Memory Center

Columbus, GA United States
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Via Christi Research

Wichita, KS United States
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Precise Research Centers

Flowood, MS United States
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