Last updated on June 2019

A Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma [IMbrave150]


Brief description of study

This study will evaluate the efficacy and safety of atezolizumab in combination with bevacizumab compared with sorafenib in participants with locally advanced or metastatic Hepatocellular Carcinoma (HCC) who have received no prior systemic treatment.

Detailed Study Description

The participants will be randomized in a 2:1 ratio to one of the two treatment arms: Arm A (experimental arm): Atezolizumab +bevacizumab; Arm B (control arm): Sorafenib

Clinical Study Identifier: NCT03434379

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City of Hope

Duarte, CA United States
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California Pacific Medical Center

San Francisco, CA United States
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Yale Cancer Center

New Haven, CT United States
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Georgetown University

Washington, WA United States
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Moffitt Cancer Center

Tampa, FL United States
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University of Chicago

Chicago, IL United States
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Henry Ford Health System

Detroit, MI United States
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Fairview Clinical Trials Services

Minneapolis, MN United States
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Stony Brook University Hospital

Stony Brook, NY United States
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Thomas Jefferson University

Philadelphia, PA United States
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SCRI

Nashville, TN United States
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Swedish Cancer Inst.

Seattle, WA United States
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Sunshine Hospital

St Albans, Australia
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Ulsan University Hosiptal

Ulsan, Korea, Republic of
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ID Clinic

Myslowice, Poland
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Kaiser Permanente - Oakland

Oakland, CA United States
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Kaiser Permanente - Roseville

Roseville, CA United States
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Kaiser Permanente - San Leandro

San Leandro, CA United States
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Kaiser Permanente - Santa Clara

Santa Clara, CA United States
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Kaiser Permanente - South San Francisco

South San Francisco, CA United States
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Kaiser Permanente - Walnut Creek

Walnut Creek, CA United States
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Bellevue Hospital

New York, NY United States
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Samsung Medical Center

Seoul, Korea, Republic of
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Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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