Last updated on August 2018

Ascorbic Acid Corticosteroids and Thiamine in Sepsis (ACTS) Trial


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Toxic Shock Syndrome | Septicemia | Metabolic Disturbance
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Adult patient (age 18 years)
  2. Suspected (cultures drawn and antibiotic given) or confirmed (via culture results) infection
  3. Receiving vasopressor (norepinephrine, phenylephrine, epinephrine, dopamine, angiotensin II or vasopressin)

Exclusion Criteria:

  1. Member of a protected population (pregnant, prisoner)
  2. Known kidney stones within the past 1 year
  3. End stage renal disease (ESRD) requiring dialysis
  4. Known Glucose-6-Phosphate Dehydrogenase deficiency
  5. Known Hemachromatosis
  6. Comfort Measures Only status
  7. Anticipated death within 24-hours despite maximal therapy (as determined by the enrolling physician)
  8. Receiving supplemental thiamine in a dose greater than that contained in a multivitamin
  9. Clinical indication for steroids (e.g. chronic use) as determined by the clinical team providing this drug
  10. Clinical indication for thiamine as determined by the clinical team providing this drug
  11. Known allergy to vitamin C, hydrocortisone, or thiamine

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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