Aortic Stenosis: Determinants of Progression, Severity and Left Ventricular Remodeling (AS-PROGRESSION)

  • End date
    Dec 10, 2025
  • participants needed
  • sponsor
    University Hospital, Rouen
Updated on 26 February 2022
heart disease
aortic valve replacement
valvular disease
left ventricular remodeling
myocardial fibrosis


Aortic stenosis (AS) is the most frequent valvulopathy in Western countries. The prevalence of AS is constantly increasing due to the aging of the population. Although significant progress has been made in understanding the pathophysiological mechanisms underlying the onset and progression of AS, there is no medical treatment to slow or prevent its progression. The only treatment available is Aortic Valve Replacement (AVR) performed by surgery or by catheterization (TAVI).

AS is associated with an increase of post-load which leads the left ventricular myocardium to hypertrophy. Associated with hypertrophy, myocardial fibrosis will gradually develop. Despite interesting data, many unknowns persist and remain to be identified.

The aim of the study is to evaluate prospectively the progression and impact of AS in 500 patients using clinical, biological, echocardiographic and MRI parameters performed annually.

Condition Aortic Valve Stenosis
Clinical Study IdentifierNCT03411317
SponsorUniversity Hospital, Rouen
Last Modified on26 February 2022


Yes No Not Sure

Inclusion Criteria

Aortic stenosis (peak aortic valve velocity (Vmax) 2.5m/s )

Exclusion Criteria

rheumatismal or congenital aortic stenosis
aortic insufficiency (grade >= 2/4)
Associated valvulopathy (grade >= 2/4)
Angina, syncope, dyspnea NYHA 3-4
Heart failure antecedent
Myocardial infarction antecedent
Severe renal failure
indication of Aortic Valve Replacement (Surgery or TAVI)
Cardiac surgery (Aorta abdominal) antecedent
Complex congenital cardiopathy
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