Cohort of Heart Failure Patients (LOOP-HF)

  • STATUS
    Recruiting
  • End date
    Jun 23, 2023
  • participants needed
    70
  • sponsor
    Hospices Civils de Lyon
Updated on 26 February 2022
heart failure
beta blockers
nt-probnp
b-type natriuretic peptide
angiotensin
congestive heart failure
cardiac resynchronization therapy
beta-adrenergic blocking agents

Summary

This is a prospective cohort study of patients with Heart Failure with an eighteen-month follow-up aimed to collect all demographic, clinical, biological and para-clinical data to study population characteristics, assess prognosis markers and occurrence of HF treatment side effects.

Congestive Heart failure is a frequent pathology and its prevalence increases with age. Its prognosis stays pejorative despite years of major therapeutical progress. In recent trials, all-cause mortality rates at 1-year reach up to 20% and 50% at 5 years.

Medical care of congestive heart failure is based on precise international recommendations. The association of Beta-Blockers, renin-angiotensin system blockers, mineralocorticoid receptor antagonists, represent the basis of the pharmacological treatment.

Cardiac resynchronization treatment and implantable cardioverter-defibrillator are additional efficient treatments that reduce events in appropriately selected patients.

Despite these improvements, the prognostic of congestive heart failure in registers is worse than those observed in randomized trials. This can be explained by differences in congestive heart failure patient populations and/or by a less rigorous medical care where treatments are not optimized.

The evaluation of medical care in congestive heart failure is today of utmost importance.

Integrating new pharmacological molecules, medical devices and the application of new recommendations have major interest for documentation and practical changes.

The main objective of this cohort will be to evaluate the evolution of the 12-month quality of life score of a HF patient and the characteristics and treatments associated with it.

Details
Condition Congestive Heart Failure
Treatment Blood sampling and Quality of life questionnaire.
Clinical Study IdentifierNCT03422991
SponsorHospices Civils de Lyon
Last Modified on26 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with congestive heart failure confirmed during
Hospitalization for cardiac decompensation
A medical follow-up for stable congestive heart failure with at least one cardiac decompensation event
NT-proBNP > 500 ng/l in the month before Baseline (or BNP > 150 ng/l)
NYHA 2
Aged over 18
Signature of the informed consent

Exclusion Criteria

Life expectancy shorter than a month
Patients on long term assistance or with heart transplant
Impossibility to give patients clear information
Loss of autonomy, dementia, major dependence
Patients without health coverage
Patient with no legal protection
Pregnant woman
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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