Accelerated iTBS for Post Partum Depression

  • End date
    Dec 31, 2021
  • participants needed
  • sponsor
    Medical University of South Carolina
Updated on 29 January 2021
depressive symptoms
depressed mood


The investigators are studying the feasibility and tolerability of 6x/day intermittent theta burst (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over the course of 3 days for women with post-partum depression. The investigators further hope to characterize the anticipated anti-depressant effect of this treatment paradigm.


This is an open-label study designed to investigate the feasibility and tolerability of a novel TMS treatment protocol to treat depression in women with post-partum depression. It is known that TMS can effectively treat depression. The FDA approved protocol lasts 6 weeks and is not feasible for many women with post-partum depression. The investigators are investigating a 3 day treatment for depression which may be more acceptable for this population. The investigators further hope to characterize the ant-depressant effect of this protocol in order to design a larger trial.

Condition Postpartum depression, Post-Partum Depression
Treatment iTBS
Clinical Study IdentifierNCT03417960
SponsorMedical University of South Carolina
Last Modified on29 January 2021


Yes No Not Sure

Inclusion Criteria

Participants must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments
Participants must be over the age of 18
Participants must meet criteria for post-partum depression: a) onset of symptoms in the first four weeks postpartum OR b) depressive symptoms starting in the third trimester and worsening postpartum
Participants must have a HRSD17 >13 at baseline

Exclusion Criteria

Participants must not be pregnant
Participants must not meet moderate or severe use disorder of any substance with the exception of Tobacco Use Disorder
Participants must not have current psychotic symptoms
Participants must not have a history of dementia or other cognitive impairment
Participants must not have active suicidal ideation requiring hospitalization or a suicide attempt within the past 3 months
Participants must not have any contraindications to receiving rTMS (e.g. metal implanted above the neck, history of seizure, any known brain lesion)
Participants must not have any unstable general medical conditions
Participants must not have had pre-eclampsia or eclampsia during pregnancy
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Phone Email

Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note