Accelerated iTBS for Post Partum Depression

  • STATUS
    Recruiting
  • End date
    Dec 31, 2021
  • participants needed
    10
  • sponsor
    Medical University of South Carolina
Updated on 29 January 2021
depressive symptoms
depressed mood

Summary

The investigators are studying the feasibility and tolerability of 6x/day intermittent theta burst (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over the course of 3 days for women with post-partum depression. The investigators further hope to characterize the anticipated anti-depressant effect of this treatment paradigm.

Description

This is an open-label study designed to investigate the feasibility and tolerability of a novel TMS treatment protocol to treat depression in women with post-partum depression. It is known that TMS can effectively treat depression. The FDA approved protocol lasts 6 weeks and is not feasible for many women with post-partum depression. The investigators are investigating a 3 day treatment for depression which may be more acceptable for this population. The investigators further hope to characterize the ant-depressant effect of this protocol in order to design a larger trial.

Details
Condition Postpartum depression, Post-Partum Depression
Treatment iTBS
Clinical Study IdentifierNCT03417960
SponsorMedical University of South Carolina
Last Modified on29 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Participants must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments
Participants must be over the age of 18
Participants must meet criteria for post-partum depression: a) onset of symptoms in the first four weeks postpartum OR b) depressive symptoms starting in the third trimester and worsening postpartum
Participants must have a HRSD17 >13 at baseline

Exclusion Criteria

Participants must not be pregnant
Participants must not meet moderate or severe use disorder of any substance with the exception of Tobacco Use Disorder
Participants must not have current psychotic symptoms
Participants must not have a history of dementia or other cognitive impairment
Participants must not have active suicidal ideation requiring hospitalization or a suicide attempt within the past 3 months
Participants must not have any contraindications to receiving rTMS (e.g. metal implanted above the neck, history of seizure, any known brain lesion)
Participants must not have any unstable general medical conditions
Participants must not have had pre-eclampsia or eclampsia during pregnancy
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