Last updated on April 2019

Transthyretin Cardiac Amyloidosis in HFpEF

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Heart Failure With Preserved Ejection Fraction
  • Age: Between 60 - 100 Years
  • Gender: Male or Female

Inclusion Criteria

  1. Resident of Southeastern Minnesota (Olmsted, Dodge, Fillmore, Mower, Freeborn, Wabasha, or Steele County)
  2. Current diagnosis of HF per NLP search
  3. Age > 60 years
  4. Clinically obtained echocardiogram within 12 months of index visit showing:
  5. EF 40% and
  6. Increased Left Ventricular (LV) wall thickness as defined by an end-diastolic left ventricular septal or posterior wall thickness (LVWTd) 20% above the upper limit of normal measured by 2D or M-mode imaging in the parasternal long (2D) or short (M-mode) axis view (12 mm).
  7. Objective evidence of HF defined as one or more of the following present within 24 months of index visit:
  8. Meet Framingham Criteria at index visit (In-patient or outpatient)
  9. Previous HF hospitalization
  10. Invasive hemodynamic documentation of elevated pulmonary capillary wedge pressure (PCWP) or left ventricular end-diastolic pressure (LVEDP) (> 18 mmHg at rest or > 25 mmHg with exercise)
  11. Left atrial enlargement + loop diuretic for HF(clinically obtained) N-terminal pro b-type natriuretic peptide (NT-proBNP) > 300 (sinus rhythm) or >900 (atrial fibrillation) pg/mL

Exclusion Criteria

  1. Documentation of previous EF < 40%
  2. Any cardiac surgery or major chest trauma within 4 weeks of index visit
  3. Presence or history of hemodynamically significant left sided valvular disease defined
  4. Greater than mild mitral stenosis
  5. Intrinsic mitral valve disease (prolapse, flail) with greater than moderate regurgitation
  6. Myocardial infarction within 4 weeks of index visit defined by typical angina, EKG changes and significant change in serial troponins. Note that chronic troponin elevation is extremely common in cardiac amyloidosis. Hospitalized patients with troponin elevation but no significant change (delta) on serial testing will NOT be excluded.
  7. Prior or current exposure to Plaquenil (Hydroxychloroquine)

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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