Intranasal Esketamine and Fentanyl for Pain in Minor Trauma

  • End date
    Dec 1, 2022
  • participants needed
  • sponsor
    Anna Meuronen, MD
Updated on 26 February 2022


Intranasal esketamine, fentanyl and placebo are compared in treatment of acute pain in adult patients with minor trauma. Study is blinded randomized placebo-controlled parallel design.

Condition Acute Pain Due to Trauma
Treatment Esketamine, Fentanyl Citrate, Saline Nasal
Clinical Study IdentifierNCT03421275
SponsorAnna Meuronen, MD
Last Modified on26 February 2022


Yes No Not Sure

Inclusion Criteria

NRS 5 or more, minor trauma, no need for immediate iv cannulation, weight 45-115 kg

Exclusion Criteria

pregnancy, breastfeeding, head trauma, severe chronic obstructive pulmonary disease (COPD), gfr under 30, liver cirrhosis, mental illness other than mild/moderate depression, sleep apnea, unstable coronary artery disease (CAD), unstable heart failure (HF), intoxication, untreated hypertension, dementia, do not understand Finnish, contraindication to nasal spray, allergy to any of the medications, bradycardia, desaturation, suspected high intracranial pressure (ICP)
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