Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia (TOCAS)

  • days left to enroll
  • participants needed
  • sponsor
    Hôpital le Vinatier
Updated on 4 October 2022
psychiatric disorder
psychotropic drugs
Accepts healthy volunteers


People with schizophrenia show disturbances in the perception of time. Among these alterations are the perturbations of the temporal order judgment. They are characterized by the fact that, as opposed to the general population, people with schizophrenia require a longer time interval between two successive stimuli to estimate which of the two events appeared first. If these alterations are now well documented, their consequences remain little explored. Among these consequences could however appear distortions of the judgment of causality (likely to underlie certain delusional interpretations) as well as a distressing experience of loss of the continuity of the lived experience (that could contribute to the alterations basic of self-awareness).


The objective of our work lies in the study of the links between temporal sequencing, subjective perception of time and causality.

To carry out this work, the investigators will rely on an experimental paradigm (derived from Michotte's paradigm) which makes it possible to explore the links between temporal sequencing and perception of causality, validated in the normal subject. subjective consequences of these alterations will be explored using a phenomenological-inspired clinical scale (EAWE time-scale items)

Condition Schizophrenia
Treatment Performances of patients and controls on temporal task
Clinical Study IdentifierNCT03432000
SponsorHôpital le Vinatier
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Subjects with schizophrenia
Age from 18 to 45 years
Diagnosis of schizophrenia according to DSM V criteria
French mother tongue
Psychotropic treatment unchanged during the month preceding the inclusion
Stable symptomatology
Normal or corrected visual acuity (> 0.8 at Snellen scale) and normal color vision
Patients who gave informed consent to participate in the study
Control subjects (healthy volunteers)
Age from 18 to 45 years
Absence of neurological and psychiatric disorders
French mother tongue

Exclusion Criteria

Recent addiction and abuse of cannabis or any other substance (according to DSM V criteria)
Neurological disorders of vascular, infectious or neurodegenerative origin
Taking somatic drugs with a cerebral or mental impact (eg corticosteroids)
Disabling sensory disturbances, and in particular visual acuity
Participation in a Neuro Cognitive Remediation Program
Schizophrenia resistant to neuroleptic treatments
Persons protected by law (pregnant women, minors, major under guardianship ...)
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