Autologous Endothelial Progenitor Cell Therapy for Reversal of Liver Cirrhosis

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    National University Hospital, Singapore
Updated on 25 February 2022
meld score
cellular therapy


This proposal translates a hypothesis driven basic research into clinical setting to determine the potential of using autologous CD133+ cells to reverse fibrosis and improve clinical outcome for patients with end stage cirrhosis. This has significant impact on the management of cirrhosis.


This is a 2 arm randomised study patients with decompensated liver cirrhosis involving minimum of 23 and maximum of 33 patients in each arm.

The investigators propose that transplantation of mobilized autologous CD133+ cells harvested from the bone marrow directly into the liver has the ability to replace and regenerate the damaged sinusoidal endothelium as well as normalize macrophage and Natural Killer (NK) cell function. The niche provided by the refenestrated endothelium can polarize the macrophage to antifibrotic phenotype as well as directly inactivate the activated myofibroblast, resulting in reversal of liver fibrosis and improvement in liver function. Transplantation of cells will be via intraportal route delivered by percutaneous cannulation of the portal vein system.

Condition End Stage Liver Disease
Treatment GCSF, Neupogen, CD133 Cells Transplantation
Clinical Study IdentifierNCT03109236
SponsorNational University Hospital, Singapore
Last Modified on25 February 2022


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