Last updated on May 2019

Myocardial Ischemia and Transfusion


Brief description of study

The purpose of this study is to compare two red blood cell transfusion strategies (liberal and restrictive) for patients who have had an acute myocardial infarction and are anemic.

Detailed Study Description

In most clinical settings, evidence suggests it is safe to wait to give a blood transfusion. However, for those who have suffered a heart attack, there is a lack of high quality evidence to guide transfusions. This 3500 subject multi-center randomized trial will fill that void.

Hospital inpatients diagnosed with myocardial infarction who have blood counts less than 10 g/dL are randomized to receive either a liberal or a restrictive transfusion strategy.

Patients randomized to the liberal transfusion strategy will receive a red blood cell transfusion anytime there is a blood count of less than 10 g/dL.

Patients randomized to the restrictive transfusion strategy are permitted to receive a blood transfusion if the blood count is below 8 g/dL and the physician believes it is in the patient's best interest. A transfusion will be strongly recommended if the blood count drops to less than 7 g/dL. If the patient has symptoms of angina (e.g., chest discomfort described as pressure or heaviness) that do not go away with medication, a blood transfusion is ordered regardless of the blood count.

The transfusions strategies will be maintained until hospital discharge for a maximum of 30 days.

Patients will be followed for 30 days for clinically relevant outcomes. Vital status will be confirmed at 180 days.

Clinical Study Identifier: NCT02981407

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VAGLAHS

Los Angeles, CA United States
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Danbury Hospital

Danbury, CT United States
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Alexian Brothers Medical Center

Elk Grove Village, IL United States
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AMITA Health

Hinsdale, IL United States
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Saint Luke's Mid America Heart

Kansas City, KS United States
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University of Louisville

Louisville, KY United States
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Boston Medical Center

Boston, MA United States
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Lahey Hospital

Burlington, MA United States
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University of Michigan

Ann Arbor, MI United States
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St. Joseph Mercy Health System

Ypsilanti, MI United States
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Essentia Health

Duluth, MN United States
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Mayo Clinic

Rochester, MN United States
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Washington University

Saint Louis, MO United States
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University of New Mexico

Albuquerque, NM United States
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Albany Medical College

Albany, NY United States
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Southside Hospital

Bay Shore, NY United States
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NYP Brooklyn Methodist

Brooklyn, NY United States
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New York Presbyterian/Queens

Flushing, NY United States
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Westchester Medical Center

Hawthorne, NY United States
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Lenox Hilll Hospital

New York, NY United States
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Rochester General Hospital

Rochester, NY United States
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University of Rochester

Rochester, NY United States
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Northwell Staten Island Hopsital

Staten Island, NY United States
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Stony Brook Medicine

Stony Brook, NY United States
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Durham Va

Durham, NC United States
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WakeMed Health and Hospital

Raleigh, NC United States
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Aultman Hospital

Canton, OH United States
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Lancaster General Hospital

Lancaster, PA United States
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PENN Presbyterian Medical Cente

Philadelphia, PA United States
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Thomas Jefferson University

Philadelphia, PA United States
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Lankenau Medical Center

Wynnewood, PA United States
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Rhode Island Hospital

Providence, RI United States
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The Miriam Hospital

Providence, RI United States
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Greenville Health System

Greenville, SC United States
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The Memphis VAMC

Memphis, TN United States
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Royal Columbian Hospital

New Westminster, BC Canada
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H pital Charles Lemoyne

Greenfield Park, QC Canada
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Recruitment Status: Open


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