Last updated on August 2020

Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Locally Advanced Rectal Cancer
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Patients undergoing pre-operative pelvic chemo-radiotherapy for histologically confirmed rectal adenocarcinoma, with the following staging: cT3N0-2, cT4N0-2, cT(any)N1-2, cT(any)N(any) CRM at-risk [AJCC version V]
  • Staging / imaging of pelvis with MRI, and CT Thorax/Abdomen
  • No evidence of metastatic disease
  • ECOG Performance Status 0 - 2
  • Age > or equal to 18 years
  • Provision of written informed consent in line with ICH-GCP guidelines

Exclusion Criteria:

  • Previous radiotherapy to the pelvic region
  • Patients in whom induction chemotherapy has been delivered prior to chemoradiotherapy
  • History of inflammatory bowel disease
  • Previous hip replacement
  • Previous bowel surgery (excluding procedures/operations which would not result in small bowel adhesions - at the discretion of the Principal Investigator)
  • Patients with other syndromes/conditions associated with increased radiosensitivity
  • Any other co-existing malignancies within the past 5 years other than non- melanoma skin cancer
  • Pregnancy or lactation at the time of proposed randomisation
  • Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the study or if it is felt by the research / medical team that the patient may not be able to comply with the protocol

Recruitment Status: Closed

Brief Description Eligibility Contact Research Team

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