Shandong Cancer Hospital Affiliated to Shandong University

  • End date
    Nov 21, 2024
  • participants needed
  • sponsor
    Shandong Cancer Hospital and Institute
Updated on 25 February 2022
breast cancer
invasive breast cancer
breast conserving surgery
whole breast irradiation


In this study,the eligible breast cancer patients will be randomized divided into two groups. the study group receive the accelerated hypo-fractioned whole breast irradiation with a concurrent boost to the tumor bed (WBI 2.5Gy x18 and SIB 2.88Gy x18) and the control group receive conventional fractioned whole breast irradiation with a concurrent boost to the tumor bed(WBI 1.8Gy x28 and SIB 2.15Gy x28). All radiotherapy will be delivered by external beam-intensity modulated radiotherapy. the purpose of this study is to assess whether the accelerated hypo-fractioned is non-inferior to the conventional fractionated radiotherapy. The outcomes evaluation will include acute toxicity , late toxicity including breast fibrosis and cardiac disease, cosmetic outcome ,local control and survival outcome.

Condition Early-stage Breast Cancer, Breast Conserving Surgery
Treatment Whole Breast irradiation Plus simultaneous tumor bed Boost
Clinical Study IdentifierNCT02958033
SponsorShandong Cancer Hospital and Institute
Last Modified on25 February 2022


Yes No Not Sure

Inclusion Criteria

Female patients has had breast conserving surgery
age 18 and 65 years
with a histological diagnosis of invasive carcinoma of the breast
with pathological stage of T1-2N0-1M0
multidisciplinary decision of adjuvant WBI with a boost to the tumor bed
informed consent obtained, signed and dated before specific protocol procedures

Exclusion Criteria

patients treated with Mastectomy
Need for lymph node irradiation
positive or close( 1 mm) surgical margin
treated with neoadjuvant chemotherapy before surgery
Bilateral malignancy of the breast (synchronous or metachronous)
Pregnant or breastfeeding
Mental condition rendering the patient unable to understand the nature, scope and possible consequences of the study
Patient unlikely to comply with the protocol; i.e. uncooperative attitude, inability to return for follow-up visits, and unlikely to complete the study
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note