Last updated on March 2019

Efficacy of Apatinib in Radioactive Iodine-refractory Differentiated Thyroid Cancer


Brief description of study

Radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) is a great challenge in the treatment of thyroid cancer. Tyrosine kinase inhibitors (TKIs), like sorafenib and lenvatinib which have been approved by food and drug administration (FDA), could not be affordable for most of the Chinese patients. Apatinib is a highly selective VEGFR2 inhibitor and reduces the angiogenesis of tumor efficiently, which had been proven effective in many solid tumors, is a Chinese domestic TKI targeting vascular endothelial growth factor receptor (VEGFR). A phase II study aims to assess the efficacy and safety of apatinib in RAIR-DTC was enrolled 20 patients, and 10 of them had obtained a shout-term efficacy,the study demonstrate the peculiar potential in treatment of RAIR-DTC. In this study, the investigators aim to further explore the efficacy and safety of apatinib in RAIR-DTC.

Detailed Study Description

Primary Outcome Measure: Progression free survival of apatinib RAIR-DTC.

Secondary Outcome Measures: Disease control rate, objective response rate, duration of response, changes of Tg and TgAb level in serum, overall survival, side effects and quality of life.

Clinical Study Identifier: NCT03048877

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Recruitment Status: Open


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