Pain Reward Attention and Neurocircuitry: Biomarkers of Suicidality

  • End date
    Sep 7, 2023
  • participants needed
  • sponsor
    Unity Health Toronto
Updated on 7 October 2021
depressed mood
depressive episode
major depressive disorder, single episode
Accepts healthy volunteers


The ultimate aim of this study is to identify a biomarker of suicide risk in MDD by measuring the "hedonic spectrum" (pain and reward responsivity), attention and its associated brain structures using brain scans (fMRI and DTI), as well as the stability of markers over time.

Condition Endogenous depression, Major depression, Suicidal Ideation, Suicide, major depressive disorder, major depressive disorders
Treatment No intervention
Clinical Study IdentifierNCT02811198
SponsorUnity Health Toronto
Last Modified on7 October 2021


Yes No Not Sure

Inclusion Criteria

DSM-5 criteria for Major Depressive Episode within a MDD, confirmed through MINI diagnosis104
Ages between 18 and 70 years
Hamilton Depression Rating Scale - 17 item (HAMD-17) > 14
Capable of giving informed consent
Groups 1 and 2 participants only: HAMD-17 item 3 (suicide) > 2
Group 2 participants only: positive history of a suicide attempt within the last six months
Group 3 participants only: positive history of a lifetime suicide attempt

Exclusion Criteria

Medical condition requiring immediate investigation or treatment
Recent (< 6 months)/current history of drug abuse/dependence (other than caffeine, or nicotine)
Lifetime history of psychosis, Bipolar I or Bipolar II; other Axis I comorbidities are allowable
No current Axis II diagnosis, confirmed by International Personality Disorder Examination (IPDE)
Participation in experimental treatment trials for the study duration
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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