Last updated on July 2020

Memory Improvement Through Nicotine Dosing (MIND) Study


Brief description of study

The purpose of the study is to see if daily transdermal nicotine is able to produce a significant cognitive, clinical and functional improvement in participants with MCI. Neuronal nicotinic receptors have long been known to play a critical role in memory function in preclinical studies, with nicotine improving attention, learning, and memory function.

The study will enroll 300 participants for a 2 year period. Participants will be randomized (50:50) to either the transdermal nicotine, beginning at 7mg/day, and increasing to 21mg/day, or placebo skin patch.

Clinical Study Identifier: NCT02720445

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Acadia Hospital

Bangor, ME United States
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Advanced Clinical Research

Meridian, ID United States
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Tulsa Clinical Research

Tulsa, OK United States
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Integrative Clinical Trials

New York, NY United States
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Syrentis Clinical Research

Santa Ana, CA United States
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Tufts Medical Center

Boston, MA United States
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Bronson Lakeview Hospital

Kalamazoo, MI United States
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Perseverance Research Center

Scottsdale, AZ United States
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Northwestern University

Chicago, IL United States
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Brain Matters Research

Delray Beach, FL United States
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Georgetown University

Washington, WA United States
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USC Rancho Los Amigos

Downey, CA United States
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Central Arkansas Veterans HS

North Little Rock, AR United States
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University of New Mexico

Albuquerque, NM United States
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University of Iowa

Iowa City, IA United States
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Associated Neurologists

Danbury, CT United States
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Hoag Memorial Hospital Presbyterian

Newport Beach, CA United States
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Sharp Mesa Vista Hospital

San Diego, CA United States
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C & R Research Services

Coral Gables, FL United States
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Donald S. Marks, MD, PC

Plymouth, MA United States
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Rapid Medical Research

Cleveland, OH United States
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Ohio State University

Columbus, OH United States
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LeHigh Valley Hospital

Allentown, PA United States
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Roper St. Francis Hospital

Charleston, SC United States
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University of Utah

Salt Lake City, UT United States
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Kingfisher Cooperative, LLC

Spokane, WA United States
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University of Wisconsin

Madison, WI United States
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JEM Research Institute

Atlantis, FL United States
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University at Buffalo

Buffalo, NY United States
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Neurology Clinic, P.C.

Cordova, TN United States
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Brain Matters Research

Stuart, FL United States
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Clarity Clinical Research

Syracuse, NY United States
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Clarity Clinical Research

Buffalo, NY United States
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Recruitment Status: Open


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