Study of Elastographic Properties of the Clot by Technical SWIRE (Shear Wave Induced Resonance Elastography)

  • STATUS
    Not Recruiting
  • participants needed
    30
  • sponsor
    University Hospital, Grenoble
Updated on 22 January 2021
heparin
clot
anticoagulants
deep vein thrombosis
blood clot
embolism
venous thrombosis
deep venous thrombosis of lower extremity
dvts

Summary

Deep vein thrombosis (DVT) is a vascular disease characterized by the formation of a thrombus within the venous system, mainly the lower limbs. The clot structure directly influences both its location, but also its progressive profile expansion material or regression and embolic migration.

Few data are available regarding the evolution of structural properties of thrombus after an acute episode of DVT. Thrombus formation is due to the polymerization of fibrinogen into fibrin. Fibrin is a viscoelastic polymer. Its mechanical properties directly determine how the thrombus responds to forces which it is subjected.

Determining the mechanical properties of the thrombus in vivo and ex vivo is expected to study its evolutionary properties.

Description

The main objective of the study is to characterize the in vivo properties of elastographic thrombus in patients with proximal deep vein thrombosis (DVT), for quantitative elastography performed at D0, D7, D30.

The ability to analyze the structural properties of the thrombus should allow us to then correlate these properties to the evolving nature of the thrombus (embolic migration or not, recanalization or not), and the effect of different treatment on the evolution of the thrombus

Details
Condition Venous Thrombosis
Treatment elastography SWIRE
Clinical Study IdentifierNCT02859532
SponsorUniversity Hospital, Grenoble
Last Modified on22 January 2021

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