Prospective Biobanking Study in Ovarian, Breast and Head and Neck Cancer Patients Aiming at Better Understand the Link Between the Molecular Alterations of the Tumor Itself, Its Microenvironment and Immune Response (SCANDARE) (SCANDARE)

  • STATUS
    Recruiting
  • End date
    Jan 25, 2029
  • participants needed
    700
  • sponsor
    Institut Curie
Updated on 25 March 2022
cancer
breast cancer
cancer chemotherapy
ovarian cancer
triple-negative breast cancer
immunomodulator
cancer of the ovary

Summary

SCANDARE is a prospective biobanking study on tumor (+/- nodes), plasma and blood samples at different time points in ovarian, triple negative breast and head and neck cancer patients. This study will allowed to identify new molecular and/or immunological biomarkers associated with clinical and biological features of the tumors. All patients will receive standard treatment according to the stage of the diseases and usual procédures.

Description

Patients will have blood and +/- tumor samples at the following times :

  1. if eligible for surgery :
    • at surgery (blood + tumor and nodes)
    • after surgery (blood)
    • 6 months after surgery if non recurrence (Blood)
    • before cycle 1 of adjuvant chemotherapy or before radiotherapy (blood + tumor biopsie and nodes if possible)
    • before cycle 2 of adjuvant chemotherapy or after radiotherapy (blood)
    • at progression (blood + tumor biopsie and nodes if possible)
  2. if eligible for neoadjuvant chemotherapy :
    • before neoadjuvant therapy (blood + tumor biopsie and nodes)
    • during neoadjuvant therapy (post cycle 1) (blood)
    • at the time of surgery (blood + tumor and nodes)
    • 6 months after surgery if non recurrence (Blood)
    • before cycle 1 of adjuvant chemotherapy or before radiotherapy (blood + tumor biopsie and nodes)
    • before cycle 2 of adjuvant chemotherapy or after radiotherapy (blood)
    • at progression (blood + tumor biopsie and nodes)

Details
Condition Ovarian Cancer, Triple-Negative Breast Cancer, Head and Neck Cancer
Treatment blood withdrawal, Tumor biopsies / Tumor surgery
Clinical Study IdentifierNCT03017573
SponsorInstitut Curie
Last Modified on25 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Tumor types
Newly diagnosed treatment-naïve ovarian cancer patients eligible for surgery or neoadjuvant chemotherapy
Newly diagnosed treatment-naïve triple-negative breast cancer patients eligible for surgery or neoadjuvant chemotherapy
Newly diagnosed treatment-naïve head and neck cancer patients eligible for surgery
Male or female patients ≥ 18 years of age
Signed informed consent

Exclusion Criteria

Male or female patients ≤18 years old
Patients with any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
Individually deprived of liberty or placed under the authority of a tutor
Patients not affiliated to the Social Security System
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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