Last updated on April 2019

Long-acting Naltrexone for Pre-release Prisoners

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Opioid Dependence
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Adult male or female inmate at MTC, BPRU, JPRU, BCCC, or MCIW and be eligible for release within 30 days
  • History of opiate disorder [meeting DSM-V criteria of dependence at the time of incarceration]
  • Suitability for XR-NTX treatment as determined by medical evaluation
  • Currently opioid-free by history, with negative urine for all opioids and no signs of opiate withdrawal
  • Willingness to enroll in XR-NTX treatment in prison [not currently in or planning to pursue agonist (methadone, buprenorphine) treatment at release]
  • Planning to live in Baltimore City or County.
  • Inmates not meeting the opioid-dependence criterion will be eligible if they were treated in an opioid agonist treatment program during the year before incarceration

Exclusion Criteria:

  • Liver function test levels greater than three times normal
  • Active medical illness that may make participation hazardous (e.g., unstable diabetes, heart disease). Adequately treated medical conditions are acceptable
  • Untreated psychiatric disorder that may make participation hazardous (e.g., untreated psychosis, bipolar disorder with mania). Adequately treated psychiatric disorders and appropriate psychotropic medications will be allowed
  • History of allergic reaction to XR-NTX
  • Current chronic pain diagnosis for which opioids are prescribed
  • Creatinine above normal limits
  • Pregnancy (for women)
  • Breast-feeding (for women)
  • Suicidal ideation (within the past 6-months)
  • Body Mass Index (BMI) > 40
  • Unadjudicated charges that may result in transfer to another facility and/or additional prison time.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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